Collection of samples for biomarker analysis is typically conducted by a trained phlebotomist at a clinic or hospital and requires a painful blood draw and several milliliters of blood. The large volume of blood required makes pediatric blood sampling difficult and the travel requirement for the collection can be burdensome for the elderly or critically ill. The Tasso-M20 device enables at-home, automated, self-collection of sample aliquots. The device automatically collects four 17.5 microliter samples in minutes with only a few easy steps and very little pain or blood loss. The accurate quantitation of two thyroid biomarkers extracted from the Tasso-M20 device and analyzed using HPLC-MS/MS was performed in this study. Thyroid hormones Thyroxine (T4) and 3,3’,5-triidothyronine (T3) are regulators of metabolism, growth, and development. The levels of T3 and T4 are useful biomarkers of overall thyroid function. Hyperthyroidism or hypothyroidism can result from autoimmune disorders, such as Graves’ disease, certain medications, thyroid cancer, and can often occur during pregnancy. Individuals suffering from thyroid dysfunction suffer from a broad range of symptoms including weakness and fatigue.

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