Current Status and Alturas’ Ongoing Response to COVID-19
Updated 23NOV2021

MS/MS Services

Expert GLP & Non-GLP LC-MS/MS and GC-MS/MS bioanalytical and biomarker quantitation services in small and large molecules- from small volatiles, antibody drug conjugates, to protein therapeutics in any biological matrix. We provide on-time delivery of quantitative bioanalytical method development, transfer, and validation, and sample analysis to support drug candidates from discovery through phase IV clinical trials.

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MS/MS Research

Our reputation as a research-intensive organization keeps us at the front of new MS/MS bioanalytical techniques. In collaboration with technology leaders, Alturas has a successful history of transferring novel ideas to productive solution for the pharmaceutical industry. Alturas reserves resources for challenging assays and rush requests.

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Resources

A known pioneer in MicroFlow Liquid Chromatography (MFLC) and its applications to small and large molecule bioanalysis, and an active contributor in applying new microsampling techniques to routine sample analysis, recent and past publications, video, newsletters, and poster presentations produced by Alturas Analytics can be found here. We have an impressive history of leading the bioanalytical services industry with contributions from our research.

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Our Blog News & Events

  • 69th ASMS Conference

    Pennsylvania Convention Center
    October 31 - November 4, 2021

    Poster Presentations: 

    Development of validated LC-MS methods using surrogate matrices for the quantification of biomarkers of clinically significant drug-drug interactions (Abstract)
    Jason Watts, Emily Taylor, Ryan Schmich, Katherine Yahvah, and Jennifer Zimmer

    A comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination using LC-MS/MS (Abstract)
    Candace Price1;Emily Taylor2; Chad Christianson2, Olga Shimelis1; Katherine Stenerson1; Neil Spooner3
    1MilliporeSigma, Bellefonte, PA, USA; 2Alturas Analytics, Inc., Moscow, ID, USA; 3Spooner Bioanalytical Solutions, Hertford, UK

    Simultaneous Quantitation of Mannose, Glucose, Fructose, and Galactose in Human Plasma and Serum by LC-MS/MS (Abstract)
    Ryan Schmich, Sharon DeChenne, Chad Christianson, and Jennifer Zimmer

  • ASMS Posters and Recent Presentations

    Alturas Analytics 21 Years

     POSTER PRESENTATIONS AT ASMS

    69th ASMS Conference on Mass Spectrometry and Allied Topics
    October 31 - November 4, 2021
    Pennsylvania Convention Center
    Philadelphia, PA

    Register

    A Comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination Using LC-MS/MS
    Virtual Presentation by Chad Christianson

    In this study, a comparison was performed between a novel sample preparation technique utilizing BioSPME (biocompatible solid phase microextraction) technology and RED (rapid equilibrium dialysis), which is considered the gold standard technique for plasma protein binding level determination. Abstract

    Development of Validated LC-MS Methods Using Surrogate Matrices for the Quantification of Biomarkers of Clinically Significant Drug-Drug Interactions
    In-person Presentation by Jason Watts

    The widespread use of caffeine makes obtaining drug-free plasma impractical, and coproporphyrin I/III are endogenous compounds. Therefore, we developed validated bioanalytical methods using surrogate matrices. Abstract

    Simultaneous Quantitation of Mannose, Glucose, Fructose, and Galactose in Human Plasma and Serum by LC-MS/MS 
    In-person Presentation by Ryan Schmich

    LC-MS/MS analysis offers a sensitive and robust method for simultaneous quantitation of mannose, glucose, fructose, and galactose. These small, hydrophilic sugars are well suited to HILIC chromatography. Abstract

    BIOANALYSIS ZONE SPOTLIGHT

    Explore a collection of insightful videos, infographics, posters, interviews, editorials, and surveys focusing on small molecule analysis using MS.

    View the Feature

    RECENT FEATURES
    Visit the Alturas Analytics website for a full listing of presentations and publications.

    Bioanalytical Perspectives on Microsampling
    Presented at the 2021 AAPS PharmSci 360
    Abstract | Presentation

    Developing a Rugged Chiral Assay for the Biomarker 2-Hydroxyglutaric Acid for Use in Routine Clinical Analysis of Plasma Samples from Oncology Studies
    Presented at the Applied Pharmaceutical Analysis 2021
    Abstract | Presentation

    Today's Challenge in Cyber Security - Defending Against Ransomware
    AAPS eChalk Talk
    Abstract | Presentation | Video On-demand

    Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
    Presented at TIDES USA: Oligonucleotide & Peptide Therapeutics
    Abstract | Poster

     

     

     

  • Scientific Presentations and Upcoming Events

    Alturas Analytics 21 Years

    AAPS eCHALK TALK

    Today’s Challenge in Cyber Security – Defending Against Ransomware
    October 6, 2021
    11:15 AM ET

    This presentation provides an overview of the increasingly prevalent cybersecurity threat, ransomware, and increases awareness of the risk for corporate leadership and Information Technology (IT) departments. Recommendations for a preventative action plan to reduce the risk of ransomware attacks and best practices for employees to follow to stop the infiltration of ransomware will be introduced. Register

    APPLIED PHARMACEUTICAL ANALYSIS 2021 PRESENTATION

    Developing a rugged chiral assay for the biomarker 2-hydroxyglutaric acid for use in routine clinical analysis of plasma samples from oncology studies
    Presented by Jennifer Zimmer, PhD

    Jennifer Zimmer, PhDInvestigators have shown that one enantiomer of hydroxyglutarate (D-2-HG) is abnormally accumulated in a variety of human cancers, such as glioblastoma, acute myeloid leukemia and cholangiocarcinoma. The isocitrate dehydrogenase (IDH) enzyme normally catalyzes the conversion of isocitrate to alpha-ketoglutarate (α-KG), but in these types of cancer, mutant IDH enzymes acquire an abnormal enzymatic activity which allows them to convert α-KG into D-2-HG. Abstract

    Presentation
    Tuesday, October 12, 2021
    1:25 PM ET

     

    Virtual Meeting
    Gold Sponsor
    October 12-14, 2021
    Register

    AAPS PHARMSCI 360 PRESENTATION

    Bioanalytical Perspectives on Microsampling
    Presented by Jason Watts, PhD

    Microsampling enables increased sampling frequency for animal and human studies and decreases barriers to clinical trial enrollment. These benefits lead to larger and more inclusive datasets, but bioanalysis of microsamples does come with unique challenges. Abstract

    Tech Spotlight
    On-demand beginning October 11, 2021

    AAPS PharmSci 360 SponsorHybrid Event - Online & Philadelphia, PA 
    Sponsor & Exhibitor
    October 17-20, 2021
    Register

    RECENT FEATURES
    Visit the Alturas Analytics website for a full listing of presentations and publications.

    Coffee Chat: the Quantitation of Multiple Oligonucleotides
    Bioanalysis Zone Coffee Chat 
    Webinar

    Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
    Presented at TIDES USA: Oligonucleotide & Peptide Therapeutics
    Abstract | Poster

    Are Remote Audits Here to Stay
    Presented at the 22nd Annual Land O' Lakes Bioanalytical Conference
    Abstract | Presentation | Video

    Highly Efficient Bioanalysis of Proteins by Immunocapture Microtips and MFLC-MS/MS
    Presented at the AAPS National Biotechnology Conference
    Abstract | Presentation | Video

     

     

     

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