MS/MS Services

Expert GLP & Non-GLP LC-MS/MS and GC-MS/MS bioanalytical and biomarker quantitation services in small and large molecules- from small volatiles, antibody drug conjugates, to protein therapeutics in any biological matrix. We provide on-time delivery of quantitative bioanalytical method development, transfer, and validation, and sample analysis to support drug candidates from discovery through phase IV clinical trials.

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MS/MS Research

Our reputation as a research-intensive organization keeps us at the front of new MS/MS bioanalytical techniques. In collaboration with technology leaders, Alturas has a successful history of transferring novel ideas to productive solution for the pharmaceutical industry. Alturas reserves resources for challenging assays and rush requests.

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Resources

A known pioneer in MicroFlow Liquid Chromatography (MFLC) and its applications to small and large molecule bioanalysis, and an active contributor in applying new microsampling techniques to routine sample analysis, recent and past publications, video, newsletters, and poster presentations produced by Alturas Analytics can be found here. We have an impressive history of leading the bioanalytical services industry with contributions from our research.

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Our Blog News & Events

  • PacMass Member's Night Social and Poster Session

    PacMass Member's Night Social and Poster Session
    Fred Hutchinson Cancer Research Center
    Seattle, WA
    November 13, 2019

    The Pacific Northwest Mass Spectrometry Group, PacMass, exists to provide a local forum for the free exchange of ideas and information concerning science, philosophy and technology as it relates to the discipline of mass spectrometry and related fields.

    Visit with Alturas representatives at the poster session or email Lori Payne, lpayne@alturasanalytics.com , to schedule a meeting. 

    POSTER PRESENTATION

    Bioanalysis of Adalimumab in Human Plasma Samples Using MSIA™ Capture and Microflow LC-MS/MS
    Sharon DeChenne
    Wednesday, November 13, 2019
    5:30 PM - 8:00 PM

    Humira ® (Adalimumab) is the top selling prescription drug in the world. It is FDA approved for the treatment of ten autoimmune diseases including rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Given the number of biosimilars pending Humira ® patent expiration in 2023, there is a need for robust and accurate methods for Adalimumab analysis. LC-MS/MS analysis offers a solution to traditional ligand binding assay selectivity challenges. MSIA™ is a precise and accurate immunocapture method that can be fully automated for fast sample preparation. 

    RECENT PUBLICATION

    Bioanalysis Published online: 16 October 2019 ahead of print

    Validating stability and selectivity in the presence of co-administered compounds
    Sharon DeChenne, Katherine Yahvah and Jennifer Zimmer


    Contract research organizations (CROs), pharmaceutical companies and regulators have extensively discussed co-administered stability since it was brought up in 2010 at the Fourth Calibration and Validation Group Workshop on Recent Issues in Regulated Bioanalysis. The questions are whether or not co-administered drugs impact the stability of an analyte, and what regulatory requirements should exist for cases of co-administered drugs. 
    Read More

    UPCOMING EVENTS

    PacMass Member's Night Social 
    and Poster Session
    Nov 13, 2019
    Poster Presentation: Sharon DeChenne
    Fred Hutchinson Cancer Research Center
    Seattle, WA

    European Bioanalysis Forum
    Nov 20-22, 2019
    Poster Presentation: Chad Christianson
    Hesperia Hotel
    Barcelona, Spain

    Society of Toxicology 59th Annual Meeting & Expo
    March 15-19, 2020
    Anaheim Convention Center
    Anaheim, CA

  • AAPS PharmSci 360 - Alturas Presentations

     

    American Association of Pharmaceutical Scientists - PharmSci 360
    Henry B. Gonzalez Convention Center 
    November 3-6, 2019

     AAPS provides a dynamic forum for the exchange of knowledge among scientists. This annual gathering is a major resource of scientific advances and provides opportunities for networking, on-going education, and professional development for pharmaceutical scientists.  This year's AAPS features the 2003 co-winner of the Nobel Prize in Chemistry, Peter Agre, M.D., as one of its plenary speakers.

     

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     Need a one-day exhibit hall-only pass?

    Engage with colleagues, visit with service providers, and view poster presentations.

    Contact us for a link and access code to register.



    SPEAKER

    Optimized Microflow LC-MS/MS Methods for the Bioanalysis of Large Molecules
    Shane Needham, Ph.D.
    Monday, November 4, 2019
    10:00 AM - 10:30 AM

     

    Dr. Needham will present optimized approaches for the LC-MS/MS bioanalysis of ADC’s, peptides and proteins. The use of microflow LC-MS, the importance of using ESI sources designed for microflow-LC-MS, and how micro solid-phase extraction and immunocapture can be used for optimal analysis of peptides and proteins by LC-MS will be discussed. Approaches for method development, validation and sample analysis will be described.  View on Website

    POSTER PRESENTATION

    Development and Validation of LC-MS/MS Methods for the Quantitation of Commonly Co-administered Drugs and in Support of Several Clinical Studies
    Presented by Ashley Davie
    Wednesday, November 6, 2019
    11:30 AM, Forum 12, Monitor 77 

     

    The 2018 FDA Guidance for the Validation of Bioanalytical Methods requires an assessment of the impact of the presence of co-administered drugs on the analytical measurement and stability of novel drug candidates. GLP-compliant methods were developed and validated in support of a clinical study that featured co-administration of itraconazole, paroxetine, cimetidine, moxifloxacin, and valproic acid with a proprietary drug candidate. Various methods involving protein-precipitation and liquid-liquid extraction were employed utilizing direct-analysis or dilution of supernatant as well as evaporation with nitrogen followed by reconstitution of analyte in organic solvent. Read the Abstract



     

    RECENT PUBLICATION

     Bioanalysis Published online: 16 October 2019 ahead of print

     Validating stability and selectivity in the presence of co-administered compounds
    Sharon DeChenne, Katherine Yahvah and Jennifer Zimmer

    Contract research organizations (CROs), pharmaceutical companies and regulators have extensively discussed co-administered stability since it was brought up in 2010 at the Fourth Calibration and Validation Group Workshop on Recent Issues in Regulated Bioanalysis. The questions are whether or not co-administered drugs impact the stability of an analyte, and what regulatory requirements should exist for cases of co-administered drugs. Read More


     

    UPCOMING EVENTS

    AAPS PharmSci 360
    Nov 3 - 6, 2019
    Speaker: Shane Needham, Ph.D.
    Poster Presentation: Ashley Davie
    Henry B. Gonzalez Convention Center
    San Antonio, TX

    PacMass Members' Night Socialand Poster Session
    Nov 13, 2019
    Poster Presentation: Sharon DeChenne
    Fred Hutchinson Cancer Research Center
    Seattle, WA

    European Bioanalysis Forum
    Nov 20-22, 2019
    Poster Presentation: Chad Christianson
    Hesperia Hotel
    Barcelona, Spain

    Society of Toxicology 59th Annual Meeting & Expo
    March 15-19, 2020
    Anaheim Convention Center
    Anaheim, CA

     

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