69th ASMS Conference

October 31, 2021

Pennsylvania Convention Center
October 31 - November 4, 2021

Poster Presentations: 

Development of validated LC-MS methods using surrogate matrices for the quantification of biomarkers of clinically significant drug-drug interactions (Abstract)
Jason Watts, Emily Taylor, Ryan Schmich, Katherine Yahvah, and Jennifer Zimmer

A comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination using LC-MS/MS (Abstract)
Candace Price¹;Emily Taylor²; Chad Christianson², Olga Shimelis¹; Katherine Stenerson¹; Neil Spooner^3
1MilliporeSigma, Bellefonte, PA, USA; ²Alturas Analytics, Inc., Moscow, ID, USA; ³Spooner Bioanalytical Solutions, Hertford, UK

Simultaneous Quantitation of Mannose, Glucose, Fructose, and Galactose in Human Plasma and Serum by LC-MS/MS (Abstract)
Ryan Schmich, Sharon DeChenne, Chad Christianson, and Jennifer Zimmer

ASMS Posters and Recent Presentations

October 28, 2021

 POSTER PRESENTATIONS AT ASMS

69th ASMS Conference on Mass Spectrometry and Allied Topics
October 31 - November 4, 2021
Pennsylvania Convention Center
Philadelphia, PA

Register

A Comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination Using LC-MS/MS
Virtual Presentation by Chad Christianson

In this study, a comparison was performed between a novel sample preparation technique utilizing BioSPME (biocompatible solid phase microextraction) technology and RED (rapid equilibrium dialysis), which is considered the gold standard technique for plasma protein binding level determination. Abstract

Development of Validated LC-MS Methods Using Surrogate Matrices for the Quantification of Biomarkers of Clinically Significant Drug-Drug Interactions
In-person Presentation by Jason Watts

The widespread use of caffeine makes obtaining drug-free plasma impractical, and coproporphyrin I/III are endogenous compounds. Therefore, we developed validated bioanalytical methods using surrogate matrices. Abstract

Simultaneous Quantitation of Mannose, Glucose, Fructose, and Galactose in Human Plasma and Serum by LC-MS/MS 
In-person Presentation by Ryan Schmich

LC-MS/MS analysis offers a sensitive and robust method for simultaneous quantitation of mannose, glucose, fructose, and galactose. These small, hydrophilic sugars are well suited to HILIC chromatography. Abstract

BIOANALYSIS ZONE SPOTLIGHT

Explore a collection of insightful videos, infographics, posters, interviews, editorials, and surveys focusing on small molecule analysis using MS.

View the Feature

RECENT FEATURES
Visit the Alturas Analytics website for a full listing of presentations and publications.

Bioanalytical Perspectives on Microsampling
Presented at the 2021 AAPS PharmSci 360
Abstract | Presentation

Developing a Rugged Chiral Assay for the Biomarker 2-Hydroxyglutaric Acid for Use in Routine Clinical Analysis of Plasma Samples from Oncology Studies
Presented at the Applied Pharmaceutical Analysis 2021
Abstract | Presentation

Today's Challenge in Cyber Security - Defending Against Ransomware
AAPS eChalk Talk
Abstract | Presentation | Video On-demand

Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
Presented at TIDES USA: Oligonucleotide & Peptide Therapeutics
Abstract | Poster

AAPS 2021 PharmSci 360

October 17, 2021

Pennsylvania Convention Center
October 17-20, 2021

Win a Pair of Beats Flex at PharmSci 360!

October 14, 2021

Scientific Presentations and Upcoming Events

October 5, 2021

AAPS eCHALK TALK

Today’s Challenge in Cyber Security – Defending Against Ransomware
October 6, 2021
11:15 AM ET

This presentation provides an overview of the increasingly prevalent cybersecurity threat, ransomware, and increases awareness of the risk for corporate leadership and Information Technology (IT) departments. Recommendations for a preventative action plan to reduce the risk of ransomware attacks and best practices for employees to follow to stop the infiltration of ransomware will be introduced. Register

APPLIED PHARMACEUTICAL ANALYSIS 2021 PRESENTATION

Developing a rugged chiral assay for the biomarker 2-hydroxyglutaric acid for use in routine clinical analysis of plasma samples from oncology studies
Presented by Jennifer Zimmer, PhD

Investigators have shown that one enantiomer of hydroxyglutarate (D-2-HG) is abnormally accumulated in a variety of human cancers, such as glioblastoma, acute myeloid leukemia and cholangiocarcinoma. The isocitrate dehydrogenase (IDH) enzyme normally catalyzes the conversion of isocitrate to alpha-ketoglutarate (α-KG), but in these types of cancer, mutant IDH enzymes acquire an abnormal enzymatic activity which allows them to convert α-KG into D-2-HG. Abstract

Presentation
Tuesday, October 12, 2021
1:25 PM ET

Virtual Meeting
Gold Sponsor
October 12-14, 2021
Register

AAPS PHARMSCI 360 PRESENTATION

Bioanalytical Perspectives on Microsampling
Presented by Jason Watts, PhD

Microsampling enables increased sampling frequency for animal and human studies and decreases barriers to clinical trial enrollment. These benefits lead to larger and more inclusive datasets, but bioanalysis of microsamples does come with unique challenges. Abstract

Tech Spotlight
On-demand beginning October 11, 2021

Hybrid Event - Online & Philadelphia, PA 
Sponsor & Exhibitor
October 17-20, 2021
Register

RECENT FEATURES
Visit the Alturas Analytics website for a full listing of presentations and publications.

Coffee Chat: the Quantitation of Multiple Oligonucleotides
Bioanalysis Zone Coffee Chat 
Webinar

Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
Presented at TIDES USA: Oligonucleotide & Peptide Therapeutics
Abstract | Poster

Are Remote Audits Here to Stay
Presented at the 22nd Annual Land O' Lakes Bioanalytical Conference
Abstract | Presentation | Video

Highly Efficient Bioanalysis of Proteins by Immunocapture Microtips and MFLC-MS/MS
Presented at the AAPS National Biotechnology Conference
Abstract | Presentation | Video