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Presentations

  • Untangling the Audit Trail: Tips for Effective Review
    QA Quality Assurance

    SQA | March 12-17, 2023

    Rachel Walker, David Schumacher, Staci Loughney, Rebecca Brainard

  • Coffee Chat: reporting requirements for ICH M10
    ICH M10

    Bioanalysis Zone | January 31, 2023

    Sara Underwood, Larry E. Elvebak II, and Eric J. Woolf

  • Updating Regulated Assays in Anticipation of ICH M10
    ICH M10

    AAPS eChalk Talk | January 11, 2023

    Jennifer Zimmer

  • Small Molecule Bioanalysis Basics
    MFLC-MS/MS Small Molecule LC-MS/MS Microflow

    ACT 2022 | November 14, 2022

    Lori Payne

  • Validation of an MFLC-MS/MS Assay for the Quantitation of a Novel Peptide, AT-01, Extracted from K2EDTA Plasma
    MFLC-MS/MS Peptides LC-MS/MS Microflow

    AAPS PharmSci 360 | October 16-19, 2022

    Winston Slocumb, Tara O’Brien, Chad Christianson, Daniel Kim, Sangeetha Bollini, and Andrew Vick

  • Validation of an MFLC-MS/MS Assay for the Quantitative Analysis of a Novel Peptide, AT-01, Extracted from K2EDTA Plasma
    MFLC-MS/MS Peptides LC-MS/MS Microflow

    ISSX/MDO | September 11-14, 2022

    Tara O’Brien, Chad Christianson, Daniel Kim, Sangeetha Bollini, and Andrew Vick

  • Accurate and Precise Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    TIDES USA | May 9-12, 2022

    Chad Christianson, Ryan Schmich, and Jennifer Zimmer

  • Defending Against Ransomware
    Ransomware IT Information Technology

    SQA | April 3-8, 2022

    Bo Cheng and David Schumacher

  • Communication Skills Promote Compliant Outcomes
    QA Quality Assurance

    SQA | April 3-8, 2022

    Rachel Walker

  • Ask the Experts: oligonucleotide analysis and therapeutics
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    Bioanalysis Zone | November 8, 2021

    Chad Christianson, et al.

  • Development of validated LC-MS methods using surrogate matrices for the quantification of biomarkers of clinically significant drug-drug interactions
    LC-MS/MS Biomarkers DDI drug-drug interactions

    ASMS | October 31 - November 4, 2021

    Jason Watts, Emily Taylor, Ryan Schmich, Katherine Yahvah, and Jennifer Zimmer

  • A Comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination using LC-MS/MS
    BioSPME Protein Binding LC-MS/MS

    ASMS | October 31 - November 4, 2021

    Candace Price, Emily Taylor, Chad Christianson, Olga Shimelis, Katherine Stenerson, and Neil Spooner

  • Coffee Chat: the Quantitation of Multiple Oligonucleotides
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    Bioanalysis Zone | August 27, 2021

    Chad Christianson, Brian Rivera, and Naamah Maundrell

  • Simultaneous Quantitation of Mannose, Glucose, Fructose, and Galactose in Human Plasma and Serum by LC-MS/MS
    LC-MS/MS Sugar

    ASMS | October 31 - November 4, 2021

    Ryan Schmich, Sharon DeChenne, Chad Christianson, and Jennifer Zimmer

  • Bioanalytical Perspectives on Microsampling
    Microsampling

    AAPS PharmSci 360 | October 17-20, 2021

    Jason Watts

  • Developing a rugged chiral assay for the biomarker 2-hydroxyglutaric acid for use in routine clinical analysis of plasma samples from oncology studies
    Biomarkers Chiral LC-MS/MS

    APA | October 12-14, 2021

    Jennifer Zimmer

  • Spotlight: Small molecule analysis using MS
    Small Molecule LC-MS/MS

    Bioanalysis Zone | October 7, 20212021

    Alturas Analytics, Charles River Laboratories, and Sciex

  • AAPS eChalk Talk: Today’s Challenge in Cyber Security – Defending Against Ransomware
    Ransomeware IT Information Technology

    AAPS | October 6, 2021

    Bo Cheng

  • Quantitation of the Phosphorothioate Oligonucleotide Mipomersen from Human Plasma by MFLC-MS/MS
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    TIDES | September 20-30, 2021

    Chad Christianson and Brian Rivera

  • Are Remote Audits Here to Stay?
    QA Quality Assurance Remote Audit Regulatory

    Land O' Lakes Bioanalytical | July 12-14, 2021

    David Schumacher

  • Highly Efficient Bioanalysis of Proteins by Immunocapture Microtips and MFLC-MS/MS
    LC-MS/MS Immunocapture Large Molecules MSIA MFLC-MS/MS Microflow ADCs

    AAPS NBC | May 17-20, 2021

    Chad Christianson

  • A Universal Method for the Quantitation of Multiple Oligonucleotides from Plasma by MFLC-MS/MS
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    AAPS NBC | May 17-20, 2021

    Chad Christianson, Ryan Schmich, and Jennifer Zimmer

  • Quality from Home: Remote Review
    QA Quality Assurance Remote Audit Regulatory

    SQA | April 12-15, 2021

    Rachel Walker, David Schumacher, and Staci Loughney

  • In the Zone: virtual audits
    QA Quality Assurance Remote Audit Regulatory

    Bioanalysis Zone | March 29, 2021

    David Schumacher

  • International Women’s Day 2021: women in bioanalysis
    Interview

    Bioanalysis Zone | March 8, 2021

    Ann Hoffman, Katherine Yahvah, et al.

  • Panel discussion: lessons learnt from COVID-19 and lab 4.0
    QA Quality Assurance Remote Audit Regulatory COVID-19 Diversity Training Employment

    Bioanalysis Zone | February 18, 2021

    Chad Briscoe, Jennifer Zimmer, Neil Walsh, Omar Barnaby, Rafiq Islam, and Joleen White

  • Post-event Report - TIDES: Oligonucleotide and Peptide Therapeutics
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    TIDES | October 23, 2021

    Chad Christianson, et al.

  • Virtual Realities: Hosting Remote Audits (including the FDA) in a Post-COVID World
    QA Quality Assurance Remote Audit Regulatory

    APA | October 12-16, 2020

    David Schumacher

  • Ready, Willing, and Stable? Advice from the LC-MS Experts on Analysis of Unstable Compounds and Prodrugs
    Prodrugs LC-MS/MS

    APA | October 12-16, 2020

    Chad Christianson

  • The FDA Virtually Knocks on the Door and Tips for Hosting Remote Audits
    QA Quality Assurance Remote Audit Regulatory

    SQA | September 21-29, 2020

    David Schumacher

  • Using an Electronic System to Record Reagent Tracking and Solution Preparation
    QA Quality Assurance

    SQA | September 21-29, 2020

    Rachel Walker, David Schumacher, and Staci Loughney

  • A Universal Method for the Quantitation of Multiple Oligonucleotides from Plasma by MFLC-MS/MS
    MFLC-MS/MS Oligos Oligonucleotides LC-MS/MS Microflow

    TIDES | September 15-18, 2020

    Chad Christianson, Ryan Schmich, and Jennifer Zimmer

  • Ask the Experts: how business continued through the COVID-19 pandemic
    COVID-19 Remote IT Quality Assurance QA Audit

    Bioanalysis Zone | July 23, 2020

    Jennifer Zimmer, et al.

  • Microsampling of Non-Invasive Matrices: Practical Examples Using Tears and a Perspective of Past and Emerging Technologies
    Microsampling MSIA DMS DBS

    Land O' Lakes Bioanalytical | July 13-16, 2020

    Jason Watts

  • Microsampling for Special Populations
    Microsampling MSIA DMS DBS

    Rozman Symposium | June 16, 2020

    Jason Watts

  • Ask the Experts: biologics by LC–MS
    LC-MS/MS Biologics

    Bioanalysis Zone | June 2, 2020

    Chad Christianson, et al.

  • An Application of Scientific Research in the Private Sector: Supporting Novel Drug Development on the Palouse

    University of Idaho Biological Engineering Department | April 13, 2020

    Jennifer Zimmer

  • Gender parity in bioanalysis
    Diversity

    Bioanalysis Zone | March 5, 2020

    Robin Woods, et al.

  • Quantitative Analysis of the Thyroid Hormone T4 Biomarker Extracted from Whole Blood Using a MITRA® Microsampling Device
    LC-MS/MS Biomarkers

    EBF | November 20-22, 2019

    Chad Christianson, Jason Watts, Katherine Yahvah, and Michael Williams

  • Bioanalysis of Adalimumab in Human Plasma Samples Using MSIA™ Capture and Microflow LC-MS/MS
    LC-MS Monoclonal Antibody Microflow MFLC-MS/MS MSIA

    PACMASS | November 13, 2019

    Sharon DeChenne, Chad Christianson, and Jennifer Zimmer

  • Development and Validation of LC-MS/MS Methods for the Quantitation of Commonly Co-administered Drugs and in Support of Several Clinical Studies
    LC-MS/MS DDI Drug-drug Interactions

    ISSX | July 28-31, 2019

    Ashley Davie, Chad Christianson, Emily Witthuhn, Ryan Schmich, Katherine Yahvah, and Jennifer Zimmer

  • Optimized Microflow LC-MS/MS Methods for the Bioanalysis of Large Molecules
    Large Molecules LC-MS/MS Microflow MFLC-MS/MS Monoclonal Antibodies

    AAPS PharmSci | November 3-6, 2019

    Shane Needham

  • MSIA (Mass Spec Immuno Assay) and MFLC-MS/MS for the Bioanalysis of Humira from Human Plasma
    LC-MS Monoclonal Antibodies Microflow MFLC-MS/MS MSIA

    CPSA USA | October 31, 2019

    Chad Christianson

  • Coffee Chat: the Importance of Patient-Centric Sampling

    Bioanalysis Zone | June 2019

    Shane Needham, Stephanie Cape, Melanie Anderson, and Naamah Maundrell

  • Strategy for Implementation of 2018 FDA Bioanalytical Method Validation Guidance and Proactively Addressing the ICH M10 BMV Draft Guideline Internally and/or with Outsourcing Partners
    ICH M10 Regulatory

    PBSS | October 3, 2019

    Katherine Yahvah

  • In the Zone: The bioanalyst – challenges and solutions
    LC-MS/MS GC-MS Multiple Metabolites Infographic Large Molecules Prodrugs

    Bioanalysis Zone | September 30, 2019

    Katherine Yahvah, Michael Williams, and Chad Christianson

  • Challenges and Solutions to the Bioanalysis of Large Molecules by LC-MS/MS: Development, Validation and Production
    LC-MS/MS ADCs Peptides Microflow MFLC-MS/MS MSIA Large Molecules

    Reid Bioanalytical Forum | September 23-26, 2019

    Shane Needham

  • Strategy for Implementation of 2018 FDA Bioanalytical Method Validation Guidance and Proactively Addressing the ICH M10 BMV Draft Guideline Internally and/or with Outsourcing Partners
    ICH M10 Regulatory

    APA | September 9-11, 2019

    Jennifer Zimmer and Jenifer Vija Session, Session
    Co-Chairs Lori Payne and Jenifer Vija

  • Quantitative Analysis of a Thyroid Hormone Biomarker Extracted from Whole Blood Using a Mitra Microsampling Device
    Microsampling LC-MS/MS Biomarkers MFLC-MS/MS Microflow

    ISSX | July 28-31, 2019

    Jason Watts, Ryan Schmich, Michael Williams, Katherine Yahvah, and Chad Christianson

  • Quantitative MFLC-MS/MS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma using Thermo Scientific MSIA microcolumns
    LC-MS/MS ADCs MSIA MFLC-MS/MS Microflow

    ASMS | June 2-6, 2019

    Chad Christianson, Jennifer Zimmer, Kwasi Antwi, Chris Ross, and Shane Needham

  • Microspray and microflow liquid chromatography, the way forward for LC-MS bioanalysis: Focus on large molecule bioanalysis
    LC-MS/MS ADCs Peptides Microflow MFLC-MS/MS MSIA Large Molecules

    Analyticon | April 29 - May 1, 2019

    Shane Needham

  • An interview with Shane Needham on the development and validation of assays
    Method Development Validation Regulatory

    Bioanalysis Zone | January 8, 2019

    Shane Needham

  • Optimized Extraction and MFLC-MS/MS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma
    LC-MS/MS ADCs Large Molecules MFLC-MS/MS Microflow

    AAPS PharmSci 360 | November 4-7, 2018

    Emily Witthuhn, Chad David Christianson, Jennifer Zimmer, Sharon DeChenne, and Shane Needham

  • Recent Trends with the Transfer from LBA to LC-MS Assays: Microflow LC-MS Applications for Large Biomolecules
    LC-MS/MS ADCs Peptides Microflow MFLC-MS/MS MSIA Large Molecules

    CPSA USA | October 16, 2018

    Shane Needham

  • Quantitative Microflow HPLC-MSMS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma
    LC-MS/MS ADCs Large Molecules MFLC-MS/MS Microflow

    APA | October 1-3, 2018

    Leslie Hvozda, Chad Christianson, Sharon DeChenne, Jennifer Zimmer, and Shane Needham

  • Sharing Scientific Data in the Public Domain: A Panel Discussion

    Bioanalysis Zone | 2018

    Amanda Wilson, Shane Needham, Jason Wrigley, Melanie Anderson, Lawrence Goo, and Patrick Liu

  • Quantitative Microflow HPLC-MSMS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma
    LC-MS/MS ADCs Large Molecules MFLC-MS/MS Microflow

    ASMS | June 3-7, 2018

    Chad Christianson, Sharon DeChenne, Jennifer Zimmer, and Shane Needham

  • Multiplex Screening for Cystine-Dense Peptides (CDP) Therapeutics Proteins by HPLC-MS/MS
    LC-MS/MS Peptides CDPs

    TIDES | May 7-10, 2018

    Mi-Youn Brusniak, Chad Christianson, Jim Olson, Emily Witthuhn, and Shane Needham

  • Soup to Nuts of Large Molecule LC–MS/MS Bioanalysis: From In Silico to Sample Preparation, Microflow and Optimal Source Design
    LC-MS/MS ADCs Peptides Microflow MFLC-MS/MS MSIA Large Molecules

    Bioanalysis Zone | 2018

    Shane Needham and Chad Christianson

  • A Connected Workflow in the Bioanalytical Lab

    CPSA Europe | February 8, 2018

    Shane Needham

  • Microspray and Microflow Liquid Chromatography: The Perfect Fit for Modern LC-MS Bioanalysis
    LC-MS/MS MFLC-MS/MS Microflow

    APA and APS | September, 2017

    Shane Needham

  • Using Real-Time Watson LIMS Data Integration and Analytics to Monitor Data Quality and Productivity, an Application of the Business Integration Program in the Bioanalytical Lab

    APS | September, 2017

    Ann Hoffman and Shane Needham

  • Quantitative HPLC-MS/MS Analysis of DM1 and DM1-MCC Extracted from Whole Blood Dried onto a Mitra® Microsampling Device
    LC-MS/MS ADCs MFLC-MS/MS Microflow

    ASMS | June 4-8, 2017

    Chad Christianson, Natalie C. Garcia, Mike D. Williams, and Katherine Yahvah

  • The Evaluation of Noviplex Plasma Prep Cards for Regulated Bioanalysis
    LC-MS/MS DBS

    AAPS | November, 2016

    Leslie Hvozda, Chad Christianson, Natalie C. Garcia, Mike D. Williams, and Katherine Yahvah

  • Quantitative Analysis and Protein Binding Determination of fXa Inhibitors in Human Plasma containing Adexanet Alfa by HPLC-MS/MS
    LC-MS/MS Protein Binding

    ASMS | June 5-9, 2016

    Chad Christianson, Janet M. Leeds, Tara Summer, Sharon DeChenne, and Ryan Collins

  • Performance of a Selective Method for Quantitation of Midazolam & its Metabolite, Developed to Monitor Drug-Drug Interactions in the Presence of Coadministered Drugs
    LC-MS/MS DDI

    ISSX | October 18-21, 2015

    Sarah Vukelich, Jennifer Zimmer, Ann Hoffman, and Shane Needham

  • Quantitative Analysis of Cotinine in Human Plasma and Urine Utilizing a Simple Supported Liquid/Liquid Exchange Extraction and GC-MS/MS
    GC-MS/MS

    ASMS | May 31-June 4, 2015

    Chad Christianson, Ekong Bassey, and Keith Miller

  • Effects of Matrix Age on Protein Binding Results Extracted with a Prototype Phospholipid Removal Plate and Analyzed using MFLC-MS/MS
    LC-MS/MS MFLC-MS/MS Microflow Protein Binding

    ASMS | June 9-13, 2013

    Chad D. Christianson, Casey Johnson, Sharon Cox, and Shane Needham

  • Utilizing MFLC-MS/MS for Large Molecule Quantitative Bioanalysis
    LC-MS/MS MFLC-MS/MS Microflow Large Molecules

    ASMS | June 9-13, 2013

    Casey Johnson, Jennifer Zimmer, Chad Christianson, and Shane Needham

  • Dextromethorphan Metabolism Profiling by the Analysis of Dried Matrix Samples Collected from Liver Microsomes In-Vitro Fluid and Analyzed by MFLC MS/MS
    LC-MS/MS MFLC-MS/MS Microflow DMS

    ASMS | May 23-26, 2012

    Chad Christianson, Tarra Fuchs-Knotts, Casey Johnson, and Shane Needham

  • Comparison of MFLC-MS/MS Validation Data of Methotrexate in Human Plasma to Conventional HPLC-MS/MS
    LC-MS/MS MFLC-MS/MS Microflow

    AAPS | October 14-18, 2012

    Chad Christianson, Casey Johnson, and Shane Needham

  • Quantitative Analysis of Hydrazine and Acetylhydrazine Using Chemical Derivatization and HPLC-MS/MS
    LC-MS/MS

    ASMS | May 23-26, 2012

    Derek Laine, Chad Christianson, Kevin Harbol, and Shane Needham
    Presented at ASMS

  • Comparison of Traditional HPLC/MS/MS and Micro Flow LC/MS/MS Sensitivity for Large Molecule Detection
    LC-MS/MS DBS MFLC-MS/MS Microflow

    NBC | May 21-23, 2012

    Chad Christianson, Shane Needham, and Steve Hobbs

  • Automated DBS Extractions in Liquid Handling Dispensing Tips and Internal Standard Addition Using Conventional Bioanalytical Instruments
    LC-MS/MS DBS

    AAPS | October 23-27, 2011

    Casey J.L. Johnson , Chad D. Christianson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham

  • Comparison of Traditional HPLC-MS/MS Sensitivity to the Sensitivity of Micro Flow Liquid Chromatography-MS/MS
    LC-MS/MS MFLC-MS/MS Microflow Large Molecules

    ASMS | June 5-9, 2011

    Chad Christianson, Shane Needham, and Steve Hobbs

  • Overcoming the Obstacles of Performing Dilutions and Internal Standard Addition to DBS Analysis Using HPLC/MS/MS
    LC-MS/MS DBS

    ASMS | June 5-9, 2011

    Chad D. Christianson, Casey J.L. Johnson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham

  • The Use of Conventional Bioanalytical Instruments to Automate DBS in Liquid Handling Dispensing Tips
    LC-MS/MS DBS

    DIA | May 3-4, 2011

    Casey J.L. Johnson , Chad D. Christianson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham

  • Determination of Fluconazole in Human CSF Using Dried Blood Spot Technique and HPLC/MS/MS
    LC-MS/MS DBS

    AAPS | 2010

    Chad Christianson, Casey Johnson, Jennifer Zimmer, and Shane Needham
    Presented at AAPS

  • Dried Matrix Spot Tears
    LC-MS/MS DMS

    APA | 2010

    Chad D. Christianson, Casey J. Johnson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham

  • Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Lidocaine from Rat and Mini-Pig Plasma
    LC-MS/MS

    ASMS | May 23-17, 2010

    Matthew Pollard, Derek Laine, Casey Johnson, Chad Christianson, and Shane Needham

  • Dried Blood Spot Analysis – Utilizing the Technique to Develop Assays in Rare or Limited Matrices
    LC-MS/MS DBS

    ASMS | May 23-17, 2010

    Chad Christianson, Casey Johnson, Jennifer Zimmer, and Shane Needham

  • Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Lidocaine from Rat and Mini-Pig Plasma
    LC-MS/MS

    ISSX | 2009

    Derek Laine, Casey Johnson, Chad Christianson, and Shane Needham

  • Dried Blood Spot Sampling in the Pharmaceutical Industry
    LC-MS/MS DBS

    DIA/PhRMA Workshop | December 8, 2009

    Chad Christianson, Shane Needham, and Derek Laine

  • Stabilization of a Peptide for Validation of HPLC/MS/MS Methods for the Quantitative Analysis of Peptides from Blood and Plasma
    LC-MS/MS Peptides

    ASMS | June 1-5, 2008

    Chad Christianson, Shane Needham, Sarah Walter, and Felix Karim

  • Method Development and cGLP Validation for the HPLC/MS/MS Bioanalysis of Vancomycin Extracted from Rat Plasma
    LC-MS/MS

    ASMS | June 1-5, 2008

    Chad Christianson, Matthew Pollard, and Shane Needham

  • Development of a Bioanalytical LC/MS/MS Assay for the Quantitative Analysis of Amikacin, Neomycin and Gentamicin in Plasma and Tissue Samples
    LC-MS/MS

    ASMS | June 1-5, 2008

    Jennifer S.D. Zimmer, Shane R. Needham, Jenny McKinnell, Bob Cass, and Dane Karr

  • Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Alprazolam, α-OH-Alprazolam and 4-OH-Alprazolam in Human Plasma
    LC-MS/MS

    ASMS | May 28 - June 1, 2006

    Chad D. Christianson, Shane R. Needham, and Jennifer S.D. Zimmer

  • Validation of a Chiral HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of the Enantiomers of Ketaconazole in Human and Dog Plasma
    LC-MS/MS Chiral

    ASMS | May 28 - June 1, 2006

    Jennifer S.D. Zimmer, Chad D. Christianson, and Shane R. Needham

  • Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Loxapine, Amoxapine, 7-OH-Loxapine and 8-OH-Loxapine in Human Plasma
    LC-MS/MS

    ASMS | May 28 - June 1, 2006

    Jennifer Zimmer, Chad Christianson, and Shane Needham

  • Development of a Novel HILIC HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Carboplatin from the Plasma of Mouse
    LC-MS/MS

    ASMS | June 5-9, 2005

    Chad Christianson and Shane Needham

  • Development of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of a Polypeptide Proteinase Inhibitor from Plasma
    LC-MS/MS Peptides

    ASMS | May 23-27, 2004

    Shane Needham and Mike T. Pearson

  • HPLC/MS/MS Quantitative Bioanalysis Used in Homeland Security and Anti-Terrorism Efforts: Analysis of Atropine Used to Protect Against Chemical Warfare Agents
    LC-MS/MS

    ASMS | June 8-12, 2003

    Shane Needham, Binying Ye, J. Richard Smith, and Benedict R. Capacio

  • Development of an HPLC/MS/MS Method for the Quantitative Bioanalysis of Vancomycin from the Plasma of Several Species: A Lesson Learned When Conventional Methods Are Unsuccessful
    LC-MS/MS

    ASMS | June 8-12, 2003

    Shane Needham, Mike T. Pearson, and Kay Huh

  • Method Validation for the Simultaneous HPLC/MS/MS Quantitation of Midazolam and 1-Hydroxymidazolam in Human Plasma
    LC-MS/MS

    ASMS | June 2-6, 2002

    Shane Needham and Binying Ye

  • A Novel Method for the HPLC/MS/MS Quantitative Analysis in Guinea Pig and Mouse Plasma of Pyridostigmine, a Pretreatment Compound for Chemical Warfare Agents
    LC-MS/MS

    ASMS | June 2-6, 2002

    Shane Needham, Binying Ye, J. Richard Smith, and William Korte

  • GLP Validation in Guinea Pig Plasma of an HPLC/MS/MS Method for the Quantitative Analysis of Pyridostigmine, a Pretreatment Compound for Chemical Warfare Agents
    LC-MS/MS

    AAPS | 2002

    Shane Needham, Binying Ye, and J. Richard Smith

Publications

  • Bioanalysis of tucatinib and metabolite, and a five-way cross-validation to support clinical pharmacokinetic analysis
    Bioanalysis LC-MS/MS PK

    Published ahead of print, Bioanalysis Vol. 14, No. 22

    Julie A Meyer, Sharon DeChenne, Charles A Foerder, & Shawna M Hengel

  • The use of automation in the bioanalytical lab
    QA Quality Assurance IT Integration Remote Audit COVID-19

    2021

    A compilation of articles, technical notes, and interviews regarding recent developments in software and automation tools for high-throughput bioanalysis and exploring how integrated systems can enhance bioanalytical sample analysis.

    Tech Note: Using an electronic system to record reagent tracking and solution preparation
    Interview: Laboratory electronic systems: 60 seconds with Bo Cheng
    Tech Note: Remote operation of a fully integrated bioanalytical lab

  • Recommendations for the content and management of Certificates of Analysis for reference standards from the GCC for bioanalysis
    GCC CRO ICH M10 Regulatory

    2021

    Joseph Bower, Jennifer Zimmer, Stacie McCown, Edward Tabler, Shane Karnik, Sumit Kar, Kurt Sales, Jennifer Vance, Colin Barry, Anahita Keyhan, Dave Williams, Todd Lester, Fabio Garofolo, Christina Satterwhite, Elizabeth Groeber, Heidi Renfrew, Jenny Lin, Stephanie Cape, Mark O'Dell, Xinping Fang, Ashley Brant, Wei Garofolo, Natasha Savoie, Roger Hayes, Sarah Simchik, Rachel Sun, Orlando Bravo, Dawn Dufield, Marsha Luna, Allan Xu, Cheikh Kane, Esme Farley, Mitesh Sanghvi, Amanda Hays, Steve Lowes, Rafiq Islam, Brian Hoffpauir, Chris Beaver, Kelly Dong & Daksha Desai-Krieger
    Bioanalysis 2021 13:8, 609-619

  • Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects

    2020

    Ariel R. Topletz‐Erickson PhD, Anthony J. Lee PhD, JoAl G. Mayor PharmD, Evelyn L. Rustia MD, Layth I. Abdulrasool MD, Amanda L. Wise MS, Ben Dailey MD, Sharon DeChenne BSc, Luke N. Walker MD, Stephen C. Alley PhD, Christopher J. Endres PhD
    The Journal of Clinical Pharmacology 2020

  • Validating stability and selectivity in the presence of co-administered compounds
    ICH M10 Regulatory

    2019

    Sharon DeChenne, Katherine Yahvah, and Jennifer Zimmer
    Bioanalysis 2019 11:20, 1819-1821

  • Perspectives on gender parity in bioanalysis: an interview with Shane Needham

    2019

    Shane R. Needham
    Bioanalysis 2019 11:7, 665-666

  • Simultaneous extraction and analysis of multiple cystine-dense peptides by µSPE and microflow MS/MS from plasma

    2019

    Mi-Youn Brusniak, Chad Christianson, Emily Witthuhn, Shane R. Needham, and James M Olson
    Bioanalysis 2019 11:6, 485-493

  • Peptide and Protein Bioanalysis using Integrated Column-to-Source Technology for High-Flow Nanospray”

    2017

    Shane R. Needham,Gary A. Valaskovic 
    Protein Analysis Using Mass Spectrometry: Accelerating Protein Biotherapeutics from Lab to Patient 2017, Chapter 5

  • Microspray and microflow liquid chromatography: the way forward for LC–MS bioanalysis

    2017

    Shane R. Needham
    Bioanalysis 2017 9:24, 1935-1937

  • Microflow LC–MS-MS: The Past, the Present, and the Path Forward
    LC-MS/MS Microflow MFLC-MS/MS

    2016

    Shane R. Needham, Michael D. Williams
    LCGC North America Volume 34:7 2016, 464–471

  • HPLC Column Technology in a Bioanalytical Contract Research Organization

    2016

    Ryan Collins, Shane Needham
    LCGC Supplements, Special Issues-04-01-2016, Volume 34, Issue 4
    Pages: 24–27

  • Clinical and Pharmaceutical Solutions through Analysis (CPSA BRASIL 2015): on the way to innovation – pharmaceutical/ analytical technology, regulation and knowledge management

    2015

    Shane Needham, Nathan Yates, Rafael Barrientos, Martin Steel, and Mike Lee
    Bioanalysis 2015 7:23, 2977-2979

  • Microspray and microflow LC-MS/MS: the perfect fit for bioanalysis

    2015

    Shane R. Needham and Gary A. Valaskovic
    Bioanalysis 2015 7:9, 1061-1064

  • Defining the Challenges of the Modern Analytical Laboratory (CPSA USA 2014): The Risks and Reality of Personalized Healthcare

    2015

    Naidong Weng, Shane R. Needham, and Mike Lee
    Bioanalysis 2015 7:4, 407-411

  • Beyond Dried Blood Spots – Application of Dried Matrix Spots
    DBS DMS

    2014

    Shane R. Needham
    Dried Blood Spots: Applications and Techniques 2014, Chapter 21

  • Conference Report (CPSA 2013): Connecting Patients and Subject Numbers through Analysis

    2014

    Shane R. Needham, Noel Premkumar, Naidong Weng, and Mike Lee
    Bioanalysis 2014 6:3, 281-285

  • Recent advances in the bioanalytical applications of dried matrix spotting for the analysis of drugs and their metabolites
    DMS DBS

    2013

    Jennifer S.D. Zimmer, Chad D. Christianson, Casey J.L. Johnson, and Shane R. Needham
    Bioanalysis 2013 5:20, 2581-2588

  • The advantages of microflow LC-MS/MS compared with conventional HPLC-MS/MS for the analysis of methotrexate from human plasma
    LC-MS/MS MFLC-MS/MS Microflow

    2013

    Chad C. Christianson, Casey J.L. Johnson, and Shane R. Needham
    Bioanalysis 2013 5:11, 1387-1396

  • Micro-LC-MS/MS: the future of bioanalysis
    LC-MS/MS

    2013

    Don W. Arnold and Shane R. Needham
    Bioanalysis 2013 5:11, 1329-1331

  • Conference Report: Transforming drug discovery and drug development through innovation: past, present, future

    2013

    Shane R. Needham, Noel Premkumar, Joanna Pols, and Mike Lee
    Bioanalysis 2013 5:3, 275-279

  • Conference Report: 4th Global CRO Council for Bioanalysis: coadministered drugs stability, EMA/US FDA Guidelines, 483s and Carryover
    CRO GCC

    2012

    Steve Lowes, Jim Jersey, Ronald Shoup, Fabio Garofolo, Shane Needham, Philippe Couerbe, Tim Lansing, Masood Bhatti, Curtis Sheldon, Roger Hayes, Rafiq Islam, Zhongping (John) Lin, Wei Garofolo, Marc Moussallie, Leonardo de Souza Teixeira, Thais Rocha, Paula Jardieu, James Truog, Jenny Lin, Richard Lundberg, Alan Breau, Carmen Dilger, Mohammed Bouhajib, Ann Levesque, Sofi Gagnon-Carignan, Rand Jenkins, Robert Nicholson, Ming Hung Lin, Shane Karnik, William DeMaio, Kirk Smith, Laura Cojocaru, Mike Allen, Saadya Fatmi, Farhad Sayyarpour, Michele Malone, and Xinping Fang
    Bioanalysis 2012 4:7, 763-768

  • Conference Report: Science and technology coming together to make a difference

    2012

    Shane R. Needham, Casey J.L. Johnson, Roger Hayes, and Mike Lee
    Bioanalysis 2012 4:4, 353-357

  • Maternal Plasma Advanced Glycation End Products Concentrations in Response to Oral 50-gram Glucose Load in Mid-Pregnancy: A Pilot Study

    2012

    Williams, M.A., Enquobahrie, D.A., Zimmer, J., Qiu, C.F, Hevner, K., Abetew, D., Christianson, C., and Sheaff, C.
    Clinical Laboratory 2012 58:9-10, 1045-1050

  • Use of conventional bioanalytical devices to automate DBS extractions in liquid-handling dispensing tips
    DBS

    2011

    Casey J.L. Johnson, Chad D. Christianson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham
    Bioanalysis 2011 3:20, 2303-2310

  • Recommendations on: internal standard criteria, stability, incurred sample reanalysis and recent 483s by the Global CRO Council for Bioanalysis

    2011

    Steve Lowes, Jim Jersey, Ronald Shoup, Fabio Garofolo, Natasha Savoie, Ejvind Mortz, Shane Needham, Maria Cruz Caturla, Ray Steffen, Curtis Sheldon, Roger Hayes, Tim Samuels, Lorella Di Donato, John Kamerud, Steve Michael, Zhongping (John) Lin, Jim Hillier, Marc Moussallie, Leonardo de Souza Teixeira, Mario Rocci, Mike Buonarati, James Truog, Saleh Hussain, Richard Lundberg, Alan Breau, Tianyi Zhang, Jianine Jonker, Neil Berger, Sofi Gagnon-Carignan, Corey Nehls, Robert Nicholson, Martijn Hilhorst, Shane Karnik, Theo de Boer, Richard Houghton, Kirk Smith, Laura Cojocaru, Mike Allen, Tammy Harter, Saadya Fatmi, Farhad Sayyarpour, Jenifer Vija, Michele Malone, and Dennis Heller
    Bioanalysis 2011 3:12, 1323-1332

  • Conference Report: Chemical and Pharmaceutical Structure Analysis 2010: From Data to Biology: Analytical Measurements to Drive Pharmaceutical R&D

    2011

    Shane R. Needham, Mike Lee, and Petia Shipkova
    Bioanalysis 2011 3:4, 359-362

  • Validation of HPLC–MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma

    2010

    Jennifer S.D. Zimmer, Shane R. Needham, Chad D. Christianson, Crystal M. Piekarski, Chrystal N. Sheaff, Keith Huie, Andrea R. Reed, and Lori Takahashi
    Bioanalysis 2010 2:12, 1989-2000

  • Development and validation of an HPLC–MS/MS method for the analysis of dexamethasone from pig synovial fluid using dried matrix spotting

    2010

    Chad D. Christianson, Derek F. Laine, Jennifer S.D. Zimmer, Casey J.L. Johnson, Chrystal N. Sheaff, Anna Carpenter, and Shane R. Needham
    Bioanalysis 2010 2:11, 1829-1837

eBooks

  • Services
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  • Tech Notes
    MFLC-MS/MS Peptides LC-MS/MS Microflow Oligos Oligonucleotides GC-MS/MS Biomarkers DDI drug-drug interactions Protein Binding Microsampling DBS DMS Pharmacokinetic Toxicokinetic PKTK ADCs CDPs

    • Multiple Oligonucleotides from Plasma by MFLC-MS/MS
    • ADC SigmaMAb Extracted from Rat Plasma Using MSIA Microcolumns
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  • Bioanalysis Zone eBook: the use of automation in the bioanalytical lab

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    • System Integration

  • Bioanalysis Zone Technology Digest: implementation of automation, IT support and cybersecurity in bioanalysis

    • Technology Digest: Implementation of automation, IT support and cybersecurity in bioanalysis
    • Ask the Experts: Conduct of remote inspections: challenges and progress
    • Infographic: The ultimate remote audit checklist
    • Perspective: Developing a strategy for a regulated electronic bioanalytical laboratory
    • Presentation Notes: Today’s challenge in cybersecurity: depending against ransomware

Newsletters

  • Celebrating 20 Years

    2021

    Alturas Advisor Special Edition

  • The Bioanalyst: Challenges and Solutions
    LC-MS/MS GC-MS Multiple Metabolites Infographic Large Molecules Prodrugs

    2019-2020

    Alturas Advisor

  • Discovery Platform for Cystine-Dense Peptides (CDP) Therapeutics Analysis by Microflow HPLC-MS/MS
    LC-MS/MS Peptides CDPs

    2018-2019

    Alturas Advisor

  • Meet ALICE: Alturas Lab Interface Communications Equipment

    2017-2018

    Alturas Advisor

  • A Better Diagnostic Test for Tuberculosis: GC-MS/MS Bioanalysis for the Determination of the Biomarker D-Arabinose in Urine
    GC-MS/MS Biomarkers

    2016-2017

    Alturas Advisor

  • Crystal City VI: Assay Criteria and Level of Validation Required for Biomarkers Will Depend Upon the Intended Purpose of the Assay
    ICH M10 Regulatory

    2015-2016

    Alturas Advisor

  • Expanding Bioanalytical & Biomarker Capabilities: Addition of TSQ Quantum XLS Ultra™ GC-MS/MS
    GC-MS/MS Biomarkers

    2014-2015

    Alturas Advisor

  • Driving Innovation in Regulated Bioanalysis through Microflow Liquid Chromatography and High Flow Nanospray Mass Spectrometry
    LC-MS/MS MFLC-MS/MS Microflow

    2013-2014

    Alturas Advisor

  • Micro Flow Liquid Chromatography (MFLC)-MS/MS Bioanalytical Research
    LC-MS/MS MFLC-MS/MS Microflow

    2012-2013

    Alturas Advisor

  • LC-MS/MS Bioanalysis of Macromolecules: Proteins and Biomarkers
    LC-MS/MS Proteins Peptides Biomarkers

    2011-2012

    Alturas Advisor

  • Research Advances with Dried Blood Spot Analysis (DBS) Coupled with LC/MS/MS
    LC-MS/MS DBS

    2010-2011

    Alturas Advisor

  • Dried Blood Spot Analysis Coupled with LC/MS/MS
    LC-MS/MS DBS

    2009-2010

    Alturas Advisor

  • Ion-Pair HPLC/MS/MS Bioanalysis: Are There Always Negative Consequences?
    LC-MS/MS

    2008-2009

    Alturas Advisor

  • HPLC/MS/MS Bioanalysis of Peptides
    LC-MS/MS Peptides

    2007-2008

    Alturas Advisor

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