Development of an HPLC/MS/MS Method for the Quantative Bioanalysis of Vancomycin from the Plasma of Several Species

Vancomycin is a glycopeptide antibiotic that is often used as a last-line of defense against bacterial infections. Since bacteria strains are becoming resistant to current antibiotics new glycopeptides are being developed.

Typically, glycopeptides are water-soluble and have molecular weights > 1400 amu. The water solubility of glycopeptides makes these compounds difficult to extract from plasma with typical liquid-liquid extraction.

The goal of this study is to find an HPLC/MS/MS method that accurately quantifies vancomycin at limits of quantitation (LLOQ) near 10 ng/mL.

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