The measurement of free and bound payloads in antibody-drug conjugates (ADCs) represents a technical challenge, especially for studies that provide limited sample volume. The method development approach needs to be efficient, accurate, and precise in order to deliver high quality data for all three measurements to regulatory bodies.
The presentation will explain the practical aspects of extraction, capture techniques, and selective/sensitive LC-MS/MS analysis to measure the free, conjugated, and total antibody measurement for studies that have limited sample volume.
This webinar provides an opportunity for laboratory personnel and development strategists to efficiently develop robust methods for free and payload bioanalysis for studies that have limited sample volume.
