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Determination of the conjugated payload concentration from an antibody drug conjugate can be obtained with several different methods. The purpose of this poster is to report the pros and cons on three different mechanisms of cleaving the payload from the ADC Anetumab-MMAE prior to analysis by LC-MS/MS. The three mechanisms tested will be a simple pellet digestion, Protein A capture/elution/digestion and Anti Human IgG1 Fc capture/elution/digestion using papain as the digestion enzyme.

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