ADCs present unique bioanalytical challenges due to their complexity and require a thorough understanding of the chemistries and interactions between each component of the conjugate. With Alturas’ research experience and recent advances in LC-MS/MS, automation and immunocapture technology, we are able to perform each component of the conjugate on a single platform. Alturas has:
- Developed and validated >30 LC-MS/MS methods for conjugated and unconjugated payloads
- Developed and validated all ADC methods in compliance with FDA and ICH bioanalytical guidelines
- Collaborated on various unique ADC programs and analyzed >30,000 ADC samples
- Analyzed thousands of protein samples by LC-MS/MS of signature peptides
