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  • Feb 1, 2023

    The FDA Virtually Knocks on the Door and Tips for Hosting Remote Audits

      About the Presenter With over 20 years in Quality Assurance, David Schumacher, RQAP-GLP since 2004, oversees the Alturas Analytics Quality Assurance Program. David is an experienced Quality Assurance Professional in FDA...

  • Feb 1, 2023

    Development of validated LC-MS methods using surrogate matrices for the quantification of biomarkers of clinically significant drug-drug interactions

      When developing a quantitative LC-MS/MS method, ideally the standard curve and quality controls should be prepared in a matrix as similar as possible to the study samples to limit the potential for dissimilar matrix components...

  • Feb 1, 2023

    A Comparison of Rapid Equilibrium Dialysis with Biocompatible Solid Phase Microextraction for Plasma Protein Binding Determination using LC-MS/MS

      Determination of protein binding levels and free circulating drug in biological systems is important in establishing pharmacokinetic activity. The portion of drug that binds to protein within the body is rendered inactive and...

  • Feb 1, 2023

    Bioanalytical Perspectives on Microsampling

      Microsampling enables increased sampling frequency for animal and human studies and decreases barriers to clinical trial enrollment. These benefits lead to larger and more inclusive datasets, but bioanalysis of microsamples...

  • Feb 1, 2023

    Developing a rugged chiral assay for the biomarker 2-hydroxyglutaric acid for use in routine clinical analysis of plasma samples from oncology studies

       Investigators have shown that one enantiomer of hydroxyglutarate (D-2-HG) is abnormally accumulated in a variety of human cancers, such as glioblastoma, acute myeloid leukemia and cholangiocarcinoma. The isocitrate...

  • Feb 1, 2023

    Are Remote Audits Here to Stay?

      COVID-19 disrupted normal operations across the entire pharmaceutical business spectrum requiring most to find innovative ways to maintain operations. Reduced hours, work from home environments and limited travel were just a...

  • Feb 1, 2023

    Highly Efficient Bioanalysis of Proteins by Immunocapture Microtips and MFLC-MS/MS

      Digestion of biomolecules in biological matrices results in the formation of thousands of peptides that can interfere with your target molecule. In-silico peptide selection, use of surfactants, immunocapture, micro-elution...

  • Feb 1, 2023

    Quality from Home: Remote Review

       Working from home is becoming an increasingly widespread practice, and FDAregulated industry is no exception. Even post-pandemic, it is likely that some staff in many companies will continue to work remotely for various...

  • Feb 1, 2023

    Virtual Realities: Hosting Remote Audits (including the FDA) in a Post-COVID World

      As the COVID-19 pandemic spread across the USA in early 2020, many facilities had to reduce operations, preventing auditors from traveling to customer sites. Alturas Analytics developed processes to permit auditors to conduct...

  • Feb 1, 2023

    Ready, Willing, and Stable? Advice from the LC-MS Experts on Analysis of Unstable Compounds and Prodrugs

      About the Presenter Chad has over 20 years of related experience as an analytical scientist with over 17 years focused on bioanalysis at Alturas Analytics. This depth of experience in applied LC–MS/MS and GC–MS/MS,...

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News & Events

Latest News

  • 03/09/2023

    SQA Poster Presentation – Untangling the Audit Trail | SOT

  • 02/22/2023

    A Message from Alturas President Robin Woods

  • 12/06/2022

    ICH M10 Webinars | Coffee Chat | eChalk Talk

  • 11/29/2022

    Join Us at AAPS and ACT | Poster: Microflow MS/MS Quantitation

  • 11/29/2022

    ACT 2022 Annual Meeting | Presentation: Small Molecule Bioanalysis Basics

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Upcoming Events

  • Apr 23-26

    2023 AAPS National Biotechnology Conference

  • Apr 24

    PBSS: Preclinical Development & IND Filing for Small Molecules: Nuts, Bolts and Best Practices

  • May 07-10

    TIDES USA: Oligonucleotide & Peptide Therapeutics

  • Jun 04-08

    71st ASMS Conference on Mass Spectrometry and Allied Topics

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