About the Presenter With over 20 years in Quality Assurance, David Schumacher, RQAP-GLP since 2004, oversees the Alturas Analytics Quality Assurance Program. David is an experienced Quality Assurance Professional in FDA...
When developing a quantitative LC-MS/MS method, ideally the standard curve and quality controls should be prepared in a matrix as similar as possible to the study samples to limit the potential for dissimilar matrix components...
Determination of protein binding levels and free circulating drug in biological systems is important in establishing pharmacokinetic activity. The portion of drug that binds to protein within the body is rendered inactive and...
Microsampling enables increased sampling frequency for animal and human studies and decreases barriers to clinical trial enrollment. These benefits lead to larger and more inclusive datasets, but bioanalysis of microsamples...
Investigators have shown that one enantiomer of hydroxyglutarate (D-2-HG) is abnormally accumulated in a variety of human cancers, such as glioblastoma, acute myeloid leukemia and cholangiocarcinoma. The isocitrate...
COVID-19 disrupted normal operations across the entire pharmaceutical business spectrum requiring most to find innovative ways to maintain operations. Reduced hours, work from home environments and limited travel were just a...
Digestion of biomolecules in biological matrices results in the formation of thousands of peptides that can interfere with your target molecule. In-silico peptide selection, use of surfactants, immunocapture, micro-elution...
Working from home is becoming an increasingly widespread practice, and FDAregulated industry is no exception. Even post-pandemic, it is likely that some staff in many companies will continue to work remotely for various...
As the COVID-19 pandemic spread across the USA in early 2020, many facilities had to reduce operations, preventing auditors from traveling to customer sites. Alturas Analytics developed processes to permit auditors to conduct...
About the Presenter Chad has over 20 years of related experience as an analytical scientist with over 17 years focused on bioanalysis at Alturas Analytics. This depth of experience in applied LC–MS/MS and GC–MS/MS,...
