Current Status and Alturas’ Ongoing Response to COVID-19
Updated 26OCT2020

Presentations

Virtual Realities: Hosting Remote Audits (including the FDA) in a Post-COVID World
Abstract

David Schumacher
Applied Pharmaceutical Analysis 2020, October 12-16, 2020, Virtual Presentation

Ready, Willing, and Stable? Advice from the LC-MS Experts on Analysis of Unstable Compounds and Prodrugs
Chad Christianson
Applied Pharmaceutical Analysis 2020October 12-16, 2020, Virtual Presentation

The FDA Virtually Knocks on the Door and Tips for Hosting Remote Audits
David Schumacher
Society of Quality Assurance, September 21-29, 2020, Virtual Presentation

Using an Electronic System to Record Reagent Tracking and Solution Preparation 
Tech Note
Video Presentation

David Schumacher, Staci Loughney, and Rachel Walker
Presented by Rachel Walker, Society of Quality Assurance, September 21-29, 2020, Virtual Presentation

A Universal Method for the Quantitation of Multiple Oligonucleotides from Plasma by MFLC-MS/MS 
Tech Note
Video Presentation

Chad Christianson, Ryan Schmich, and Jennifer Zimmer
Presented by Chad Christianson, Tides: Oligonucleotide and Peptide Therapeutics, September 15-18, 2020, Boston, MA

Ask the Experts: how business continued through the COVID-19 pandemic
Interview including Jennifer Zimmer
Bioanalysis Zone, July 23, 2020

Microsampling of Non-Invasive Matrices: Practical Examples Using Tears and a Perspective of Past and Emerging Technologies 
Presentation Tech Note
Jason Watts
Land O' Lakes 21st Annual Bioanalytical Conference, July 13-16, 2020, Virtual Presentation

Microsampling for Special Populations
Video Presentation
Jason Watts
Annual Rozman Symposium, June 16, 2020, via Zoom

Ask the Experts: biologics by LC–MS
Interview including Chad Christianson
Bioanalysis Zone, June 2, 2020

An Application of Scientific Research in the Private Sector: Supporting Novel Drug Development on the Palouse
Jennifer Zimmer
University of Idaho Biological Engineering Department, April 13, 2020, Virtual Seminar

Gender parity in bioanalysis: panel discussion round-up
Panel Discussion including Robin Woods
Bioanalysis Zone, March 5, 2020

Quantitative Analysis of the Thyroid Hormone T4 Biomarker Extracted from Whole Blood Using a MITRA® Microsampling Device
Chad Christianson, Jason Watts, Katherine Yahvah, and Michael Williams 
Presented by Chad Christianson, European Bioanalysis Forum (EBF), November 20-22, 2019, Barcelona, Spain

Bioanalysis of Adalimumab in Human Plasma Samples Using MSIA™ Capture and Microflow LC-MS/MS
Sharon DeChenne, Chad Christianson, and Jennifer Zimmer
Presented by Sharon Dechenne, PacMass Member's Night and Poster Session, November 13, 2019, Seattle, WA

Development and Validation of LC-MS/MS Methods for the Quantitation of Commonly Co-administered Drugs and in Support of Several Clinical Studies
Ashley Davie, Chad Christianson, Emily Witthuhn, Ryan Schmich, Katherine Yahvah, and Jennifer Zimmer
Presented by Ashley Davie at AAPS PharmSci, November 3-6, 2019, San Antonio, TX, APA, September 9-11, 2019, Boston, MA and by Ryan Schmich at ISSX, July 28-31, 2019, Portland, OR

Optimized Microflow LC-MS/MS Methods for the Bioanalysis of Large Molecules
Shane Needham
AAPS PharmSci, November 3-6, 2019, San Antonio, TX

MSIA (Mass Spec Immuno Assay) and MFLC-MS/MS for the Bioanalysis of Humira from Human Plasma
Chad Christianson
Presented at 
CPSA USA, October 31, 2019, Langhorne, PA

Building a Better Clinical Diagnostics / Bioanalytical Mass Spectrometry Lab
Instructors Mark Hayward and Ganesh Moorthy, with Guest Discussion Leader Shane Needham
Short Course 5 at CPSA USA, October 28, 2019, Langhorne, PA

Strategy for Implementation of 2018 FDA Bioanalytical Method Validation Guidance and Proactively Addressing the ICH M10 BMV Draft Guideline Internally and/or with Outsourcing Partners
Katherine Yahvah
Presented at PBSS, October 3, 2019, Foster City, CA

In the Zone: The bioanalyst – challenges and solutions
Katherine Yahvah, Michael Williams, and Chad Christianson
Bioanalysis Zone, September 30, 2019

Challenges and Solutions to the Bioanalysis of Large Molecules by LC-MS/MS: Development, Validation and Production
Shane Needham
Presented at the 23rd International Reid Bioanalytical Forum, September 23-26, 2019, Cambridge, United Kingdom

Strategy for Implementation of 2018 FDA Bioanalytical Method Validation Guidance and Proactively Addressing the ICH M10 BMV Draft Guideline Internally and/or with Outsourcing Partners
Jennifer Zimmer and Jenifer Vija Session, Session Co-Chairs Lori Payne and Jenifer Vija
Presented at APA, September 9-11, 2019, Boston, MA

Quantitative Analysis of a Thyroid Hormone Biomarker Extracted from Whole Blood Using a Mitra Microsampling Device 
Jason Watts, Ryan Schmich, Michael Williams, Katherine Yahvah, and Chad Christianson
Presented by Jason Watts at ISSX, July 28-31, 2019, Portland, OR and by Michael Williams at APA, September 9-11, 2019, Boston, MA

Quantitative MFLC-MS/MS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma using Thermo Scientific MSIA microcolumns
Chad Christianson, Jennifer Zimmer, Kwasi Antwi, Chris Ross, and Shane Needham
Presented by Chad Christianson at ASMS, June 2-6, 2019, Atlanta, GA

Microspray and microflow liquid chromatography, the way forward for LC-MS bioanalysis: Focus on large molecule bioanalysis 
Shane Needham
Presented at Analyticon, April 29 - May 1, 2019, San Francisco, CA

Optimized Extraction and MFLC-MS/MS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma
Emily Witthuhn, Chad David Christianson, Jennifer Zimmer, Sharon DeChenne, and Shane Needham
Presented by Chad Christianson at AAPS PharmSci 360, November 4-7, 2018, Washington, DC

Recent Trends with the Transfer from LBA to LC-MS Assays: Microflow LC-MS Applications for Large Biomolecules
Shane Needham
Presented at CPSA USA, October 16, 2018, Langhorne, PA

Quantitative Microflow HPLC-MSMS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma

Leslie Hvozda, Chad Christianson, Sharon DeChenne, Jennifer Zimmer, and Shane Needham
Presented at the 14th Annual APA Meeting, Oct 1-3, 2018, Boston, MA

Sharing Scientific Data in the Public Domain: A Panel Discussion
Chaired by Amanda Wilson (AstraZeneca), with Industry Leaders Shane Needham (Alturas Analytics), Jason Wrigley (Merck KGaA), Melanie Anderson (Merck), Lawrence Goo (KCAS), and Patrick Liu (Teva pharmaceuticals)
Bioanalysis Zone Panel Discussion, 2018
(Watch On Demand)

Quantitative Microflow HPLC-MSMS Analysis of the Antibody Drug Conjugate SigmaMAb Extracted from Rat Plasma
- view abstract
Chad Christianson, Sharon DeChenne, Jennifer Zimmer, and Shane Needham
Presented at the 66th ASMS Conference on Mass Spectrometry and Allied Topics, June 3-7, 2018, San Diego, CA

Multiplex Screening for Cystine-Dense Peptides (CDP) Therapeutics Proteins by HPLC-MS/MS - view abstract
Mi-Youn Brusniak, Chad Christianson, Jim Olson, Emily Witthuhn, and Shane Needham
Presented at TIDES: Oligonucleotides and Peptide Therapeutics, May 7-10, 2018, Boston, MA

A Connected Workflow in the Bioanalytical Lab
Shane Needham
Presented
at the European Symposium on Clinical & Pharmaceutical Solutions through Analysis (CPSA) Symposium Session 5, February 8, 2018, 10:15, Cambridge, UK

Video File of presentation

Microspray and Microflow Liquid Chromatography: The Perfect Fit for Modern LC-MS Bioanalysis
Shane Needham
Presented at 13
th Boston Society APA and APS Conference, September, 2017, Providence, RI

Using Real-Time Watson LIMS Data Integration and Analytics to Monitor Data Quality and Productivity, an Application of the Business Integration Program in the Bioanalytical Lab
Ann Hoffman and Shane Needham
Presented at APS, September, 2017, Providence, RI

Quantitative HPLC-MS/MS Analysis of DM1 and DM1-MCC Extracted from Whole Blood Dried onto a Mitra® Microsampling Device
Chad Christianson, Natalie C. Garcia, Mike D. Williams, and Katherine Yahvah 
Presented at ASMS, June 4-8, 2017, Indianapolis, IN

The Evaluation of Noviplex Plasma Prep Cards for Regulated Bioanalysis

Chad Christianson, Natalie C. Garcia, Mike D. Williams, and Katherine Yahvah 
Presented at AAPS, November, 2016, Denver, CO

Quantitative Analysis and Protein Binding Determination of fXa Inhibitors in Human Plasma containing Adexanet Alfa by HPLC-MS/MS
Chad Christianson, Janet M. Leeds, Tara Summer, Sharon DeChenne, and Ryan Collins
Presented at ASMS, June 5-9, 2016, San Antonio, TX

Performance of a Selective Method for Quantitation of Midazolam & its Metabolite, Developed to Monitor Drug-Drug Interactions in the Presence of Coadministered Drugs
Sarah Vukelich, Jennifer Zimmer, Ann Hoffman, and Shane Needham
Presented at ISSX, Oct. 18-21, 2015, Orlando, FL

Quantitative Analysis of Cotinine in Human Plasma and Urine Utilizing a Simple Supported Liquid/Liquid Exchange Extraction and GC-MS/MS
Chad Christianson, Ekong Bassey, and Keith Miller
Presented at ASMS, May 31-June 4, 2015, St. Louis, MO

Effects of Matrix Age on Protein Binding Results Extracted with a Prototype Phospholipid Removal Plate and Analyzed using MFLC-MS/MS
Chad D. Christianson, Casey Johnson, Sharon Cox, and Shane R. Needham
Presented at ASMS, June 9-13, 2013, Minneapolis, MN

Utilizing MFLC-MS/MS for Large Molecule Quantitative Bioanalysis
Casey Johnson, Jennifer Zimmer, Chad Christianson, and Shane Needham
Presented at ASMS, June 9-13, 2013, Minneapolis, MN

Comparison of MFLC-MS/MS Validation Data of Methotrexate in Human Plasma to Conventional HPLC-MS/MS
Chad Christianson, Casey Johnson, and Shane Needham
Presented at AAPS, October 14-18, 2012, Chicago, IL

Dextromethorphan Metabolism Profiling by the Analysis of Dried Matrix Samples Collected from Liver Microsomes In-Vitro Fluid and Analyzed by MFLC MS/MS
Chad Christianson, Tarra Fuchs-Knotts, Casey Johnson, and Shane Needham 
Presented at ASMS, May 23-26, 2012, Vancouver, BC, Canada

Quantitative Analysis of Hydrazine and Acetylhydrazine Using Chemical Derivatization and HPLC-MS/MS
Derek Laine, Chad Christianson, Kevin Harbol, and Shane Needham
Presented at ASMS, May 23-26, 2012, Vancouver, BC, Canada

Comparison of Traditional HPLC/MS/MS and Micro Flow LC/MS/MS Sensitivity for Large Molecule Detection
Chad Christianson, Shane Needham, and Steve Hobbs
Presented at NBC, May 21-23, 2012, San Diego, CA

Automated DBS Extractions in Liquid Handling Dispensing Tips and Internal Standard Addition Using Conventional Bioanalytical Instruments
Casey J.L. Johnson , Chad D. Christianson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham
Presented at AAPS, October 23-27, 2011, Washington, DC

Comparison of Traditional HPLC-MS/MS Sensitivity to the Sensitivity of Micro Flow Liquid Chromatography-MS/MS
Chad Christianson, Shane Needham, and Steve Hobbs
Presented at ASMS, June 5-9, 2011, Denver, CO

Overcoming the Obstacles of Performing Dilutions and Internal Standard Addition to DBS Analysis Using HPLC/MS/MS
Chad D. Christianson, Casey J.L. Johnson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham
Presented at ASMS, June 5-9, 2011, Denver, CO

The Use of Conventional Bioanalytical Instruments to Automate DBS in Liquid Handling Dispensing Tips
Casey J.L. Johnson , Chad D. Christianson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham
Presented at DIA, May 3-4, 2011, Philadelphia , PA

Determination of Fluconazole in Human CSF Using Dried Blood Spot Technique and HPLC/MS/MS
Chad Christianson, Casey Johnson, Jennifer Zimmer and Shane Needham
Presented at AAPS, 2010, New Orleans, LA

Dried Matrix Spot Tears
Chad D. Christianson, Casey J. Johnson, Chrystal N. Sheaff, Derek F. Laine, Jennifer S.D. Zimmer, and Shane R. Needham
Presented at APA, 2010, Baltimore, MD

Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Lidocaine from Rat and Mini-Pig Plasma
Matthew Pollard, Derek Laine, Casey Johnson, Chad Christianson, and Shane Needham
Presented at ASMS, May 23-17, 2010, Salt Lake City, UT

Dried Blood Spot Analysis – Utilizing the Technique to Develop Assays in Rare or Limited Matrices
Chad Christianson, Casey Johnson, Jennifer Zimmer and Shane Needham
Presented at ASMS, May 23-17, 2010, Salt Lake City, UT

Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Lidocaine from Rat and Mini-Pig Plasma
Derek Laine, Casey Johnson, Chad Christianson, and Shane Needham
Presented at ISSX, 2009, Baltimore, MD

Dried Blood Spot Sampling in the Pharmaceutical Industry
Chad Christianson, Shane Needham, and Derek Laine
Presented at DIA/PhRMA Workshop, December 8, 2009, Washington, DC

Stabilization of a Peptide for Validation of HPLC/MS/MS Methods for the Quantitative Analysis of Peptides from Blood and Plasma
Chad Christianson, Shane Needham, Sarah Walter, and Felix Karim
Presented at ASMS, June 1-5, 2008, Denver, CO

Method Development and cGLP Validation for the HPLC/MS/MS Bioanalysis of Vancomycin Extracted from Rat Plasma
Chad Christianson, Matthew Pollard, and Shane Needham
Presented at ASMS, June 1-5, 2008, Denver, CO

Development of a Bioanalytical LC/MS/MS Assay for the Quantitative Analysis of Amikacin, Neomycin and Gentamicin in Plasma and Tissue Samples
Jennifer S.D. Zimmer, Shane R. Needham, Jenny McKinnell, Bob Cass, and Dane Karr
Presented at ASMS, June 1-5, 2008, Denver, CO

Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Alprazolam, α-OH-Alprazolam and 4-OH-Alprazolam in Human Plasma
Chad D. Christianson, Shane R. Needham, and Jennifer S.D. Zimmer
Presented at ASMS, May 28 - June 1, 2006, Seattle, WA

Validation of a Chiral HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of the Enantiomers of Ketaconazole in Human and Dog Plasma
Jennifer S.D. Zimmer, Chad D. Christianson and Shane R. Needham
Presented at ASMS, May 28 - June 1, 2006, Seattle, WA

Validation of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Loxapine, Amoxapine, 7-OH-Loxapine and 8-OH-Loxapine in Human Plasma
Jennifer Zimmer, Chad Christianson, and Shane Needham
Presented at ASMS, May 28 - June 1, 2006, Seattle, WA

Development of a Novel HILIC HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of Carboplatin from the Plasma of Mouse
Chad Christianson and Shane Needham
Presented at ASMS, June 5-9, 2005, San Antonio, TX

Development of an HPLC/MS/MS Bioanalytical Method for the Quantitative Analysis of a Polypeptide Proteinase Inhibitor from Plasma
Shane Needham and Mike T. Pearson
Presented at ASMS, May 23-27, 2004, Nashville, TN

HPLC/MS/MS Quantitative Bioanalysis Used in Homeland Security and Anti-Terrorism Efforts: Analysis of Atropine Used to Protect Against Chemical Warfare Agents
Shane Needham, Binying Ye, J. Richard Smith, and Benedict R. Capacio
Presented at ASMS, June 8-12, 2003, Montreal, QC, Canada

Development of an HPLC/MS/MS Method for the Quantative Bioanalysis of Vancomycin from the Plasma of Several Species: A Lesson Learned When Conventional Methods Are Unsuccessful
Shane Needham, Mike T. Pearson, and Kay Huh
Presented at ASMS, June 8-12, 2003, Montreal, QC, Canada

Method Validation for the Simultaneous HPLC/MS/MS Quantitation of Midazolam and 1-Hydroxymidazolam in Human Plasma
Shane Needham and Binying Ye
Presented at ASMS, June 2-6, 2002, Orlando, FL

A Novel Method for the HPLC/MS/MS Quantitative Analysis in Guinea Pig and Mouse Plasma of Pyridostigmine, a Pretreatment Compound for Chemical Warfare Agents
Shane Needham, Binying Ye, J. Richard Smith, and William Korte
Presented at ASMS, June 2-6, 2002, Orlando, FL

GLP Validation in Guinea Pig Plasma of an HPLC/MS/MS Method for the Quantitative Analysis of Pyridostigmine, a Pretreatment Compound for Chemical Warfare Agents
Shane Needham, Binying Ye, and J. Richard Smith
Presented at AAPS, 2002, Toronto, Canada

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