Publications
Selected Publications
Shane R Needham, “Peptide and Protein Bioanalysis using Integrated Column-to-Source Technology for High-Flow Nanospray” Chapter 5, Protein Analysis Using Mass Spectrometry: Accelerating Protein Biotherapeutics from Lab to Patient, Wiley, 2017, Mike S. Lee Editor.
Shane R Needham, "Microspray and microflow liquid chromatography: the way forward for LC–MS bioanalysis" Bioanalysis, Vol. 9, No. 24: 1935-1937. 2017. Editorial.
Ryan Collins, Shane Needham "HPLC Column Technology in a Bioanalytical Contract Research Organization"
LC/GC Magazine - Chromatographyonline.com, Apr 01, 2016, Special Issues, Volume 34, Issue 4, pg 24–27
A Better Diagnostic for Tuberculosis: GC-MS/MS Bioanalysis for the Determination of the Biomarker D-Arabinose in Urine
A collaborative article with The Global Good Fund and Alturas Analytics, Inc.
Shane Needham, Nathan Yates, Rafael Barrientos, Martin Steel and Mike Lee “Clinical and Pharmaceutical Solutions through Analysis (CPSA BRASIL 2015): on the way to innovation – pharmaceutical/ analytical technology, regulation and knowledge management” Bioanalysis (2015) 7(23), 2977–2979
Shane Needham and Gary Valoskovic “Microspray and microflow LC-MS/MS: the perfect fit for bioanalysis" Bioanalysis, Vol. 7, No. 9: 1061-1064.
Naidong Weng, Shane Needham, and Mike Lee “Defining the Challenges of the Modern Analytical Laboratory (CPSA USA 2014): The Risks and Reality of Personalized Healthcare” Bioanalysis, Vol. 7, No. 4: 407-411.
Shane R Needham, “Beyond Dried Blood Spots – Application of Dried Matrix Spots” Chapter 21, Dried Blood Spots: Applications and Techniques, Wiley, 2014, Li and Lee Editors.
Shane R Needham, Noel Premkumar, Naidong Weng and Mike Lee, and, “Conference Report (CPSA 2013): Connecting Patients and Subject Numbers through Analysis” Bioanalysis, Vol. 6, No. 3: 281-285. 2014.
Jennifer SD Zimmer, Chad D Christianson, Casey JL Johnson, and Shane R Needham “Recent advances in the bioanalytical applications of dried matrix spotting for the analysis of drugs and their metabolites” Bioanalysis, Vol. 5, No. 20: 2581-2588. 2013.
Casey JL Johnson, Chad D Christianson and Shane R Needham, “The advantages of microflow LC-MS/MS compared with conventional HPLC-MS/MS for the analysis of methotrexate from human plasma” Bioanalysis, Vol. 5, No. 11: 1387-1396. 2013.
DW Arnold and Shane R Needham, “Micro-LC-MS/MS: the future of bioanalysis” Bioanalysis, Vol. 5, No. 11: 1329-1331. 2013.
Shane R Needham, Casey JL Johnson, Roger Hayes and Mike Lee, and, “Conference Report: Transforming drug discovery and drug development through innovation: past, present, future” Bioanalysis, Vol. 5, No. 3: 275-279. 2013.
Shane R Needham, et. al., “Conference Report: 4th Global CRO Council for Bioanalysis: coadministered drugs stability, EMA/US FDA Guidelines, 483s and Carryover”, Bioanalysis, Vol. 4, No. 7: 763-768, 2012.
Shane R Needham, Casey JL Johnson, Roger Hayes and Mike Lee, and, “Conference Report: Science and technology coming together to make a difference” Bioanalysis, Vol. 4, No. 4: 353-357. 2012.
Williams, M.A., Enquobahrie, D.A., Zimmer, J., Qiu, C.F, Hevner, K., Abetew, D., Christianson, C., and Sheaff, C. Maternal Plasma Advanced Glycation End Products Concentrations in Response to Oral 50-gram Glucose Load in Mid-Pregnancy: A Pilot Study. Clinical Laboratory 58(9-10): 1045-1050 (2012).
Casey JL Johnson, Chad D Christianson, Chrystal N Sheaff, Derek F Laine, Jennifer SD Zimmer, and Shane R Needham, “Use of conventional bioanalytical devices to automate DBS extractions in liquid-handling dispensing tips” Bioanalysis, Vol. 3, No. 20: 2303-2310. 2011.
Shane R Needham, et. al., “Recommendations on: internal standard criteria, stability, incurred sample reanalysis and recent 483s by the Global CRO Council for Bioanalysis”, Bioanalysis, Vol. 3, No. 12, 1323-1332, 2011.
Shane R Needham, Mike Lee and Petia Shipkova., “Conference Report: Chemical and Pharmaceutical Structure Analysis 2010: From Data to Biology: Analytical Measurements to Drive Pharmaceutical R&D”, Bioanalysis, Vol. 3, No. 4, 359-362, 2011.
Jennifer SD Zimmer, Shane R Needham, Chad D Christianson, Crystal M Piekarski, Chrystal N Sheaff, Keith Huie, Andrea R Reed, and Lori Takahashi. “Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.” Bioanalysis, Vol. 2, No. 12: 1989-2000. 2010.
Chad D Christianson, Derek F Laine, Jennifer SD Zimmer, Casey JL Johnson, Chrystal N Sheaff, Anna Carpenter, and Shane R Needham. “Development and validation of an HPLC-MS/MS method for the analysis of dexamethasone from pig synovial fluid using dried matrix spotting.” Bioanalysis, Vol. 2, No. 11: 1829-1837. 2010.
Needham, S. R. Binying Ye, J. Richard Smith and William D. Korte. “Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Pyridostigmine Bromide from Guinea Pig Plasma.” Journal of Chromatography B. 796. 347-354. 2003.
Needham, S.R. “Bioanalytical Method Validation: Example, HPLC/MS/MS Bioanalysis of an Anti-Nerve Gas Agent Drug for Homeland Security.” American Pharmaceutical Review Summer Issue 2003.
Needham, S. R. and Tim Wehr. “Fast, Efficient Separations in Drug Discovery: LC/MS Analysis Using Column-Switching and Rapid Gradients.” LC-GC Europe April, 2001.
Needham, S. R. and P. Brown. “The Role of the Column for the Analysis of Drugs and Other Components by HPLC/MS: Part II.” American Pharmaceutical Review Spring Issue 2001.
Needham, S. R. and P. Brown. “The Role of the Column for the Analysis of Drugs and Other Components by HPLC/MS: Part I.” American Pharmaceutical Review Winter Issue 2000.
Needham, S. R.. “Fast, Efficient Separations in Drug Discovery: LC/MS Analysis Using Column-Switching and Rapid Gradients.” LC-GC November, 2000 (editors request).
Needham, S. R., P. Jeanville, P. Brown and E. Estapé. “Performance of a Pentafluorophenylpropyl Stationary Phase for the High Performance Liquid Chromatography/Mass Spectrometry/Mass Spectrometry Assay of Cocaine and its Metabolite, Ecogine Methyl Ester in Human Urine.” Journal of Chromatography B. 748. 77-88. 2000.
Needham, S. R., P. Brown, K. Duff and D. Bell. “Optimized Stationary Phases for the HPLC/ESI/MS Analysis of Basic Pharmaceuticals.” J. of Chromatogr. A. 869. 159-170. 2000.
Needham, S. R., Patrick M. Jeanville, Estela S. Estapé and Mark J. Cole. “Rapid Confirmation/Quantitation of Cocaine and Benzoylecgonine in Urine Utilizing High Performance Liquid Chromatography and Tandem Mass Spectrometry.” Journal of the American Societry for Mass Spectrometry. 11:3:257-263. 2000.